Research Programme

Malaysia Genome Institute (GENOMalaysia) was initiated in 2002 as an interim laboratory at Universiti Kebangsaan Malaysia (UKM) to develop and administer a number of core research facilities and laboratories in genomics and molecular biology. It was formally formed under MOSTI in 2007 when the organizational structure was approved.

The core business of the Institute is R&D for the generation of new knowledge and intellectual properties for commercialisation. Under the 9th MP the R&D programme commenced in 2006 with 13 multi-institutional collaborative projects under the purview of the Genomics and Molecular Biology R&D Initiatives Programme. By the end of the 9th MP in 2010, a total of 23 projects were undertaken. GENOME MALAYSIA also oversees a number of international collaborative projects and pre-commercialisation projects.

Genomics & Molecular Biology Initiatives Programme (9th MP)

No. PROJECT
1. Structural Genomics of Burkholderia pseudomallei Essential Genes and Transcription Factors
2. Comparative Genomics of Eimeria Species
3. Asian Sea Bass Genomics for Genetic Improvement
4. Development of Novel Technology for Accurate Function Prediction Based on Protein 3D Structure and Molecular Interaction Information
5. Identification of Novel Molecular Signatures as Potential Drug Targets for Diseases in Fisheries and Livestock
6. Consolidated Bioprocessing of Oil Palm Lignocellulosic BioMass: Molecular and Bioprocessing Approaches
7. Novel Systems Biology Approach Towards Elucidation of Biosynthesis Networks of Secondary Metabolites
8. Genome and Functional Analyses of Newcastle Disease Virus
9. Biosynthesis of Secondary Metabolites: Engineering the biosynthetic pathway for over-production of flavonoids and chalcones in plants and microbes cell culture
10. Development of Excretory Expression System for Enzyme / Protein Production in Bacteria and Fungi
11. Development of Selected Industrial Enzymes and Protein from Psychrophiles
12. Development of Yeast Systems for Producing Industrially Important Enzymes
13 Building of Genomics-led Green Chemistry for Industrial Biotechnology
14. Dengue Virus Genome: Dynamic s of Dengue Viruses Antigenic Epitopes In Recurring Dengue
15. Cancer Epigenomics: Whole Genome Metylation Analysis of Breast and Colorectal Cancer
16. Whole Genome Sequencing of the Extremophiles Leucospodorium sp. And Bacillus G1
17. Systems Biology of a Psychrophilic Yearst for Novel Biotechnology
18. Designer Biocatalysts for Sustainable Processes in the Conversion of Renewable Raw Materials to Platform Chemicals
19 Space Crystalisation of Industrial Enzymes onboard The Japanese Experimental Module (JEM)
20 Application of novel matrix attachment region (MAR) elements for the development of high expression system in mammalian cells for production of complex recombinant proteins
21 Design and Development of Microbial Cell Factories for Biomolecules Production and Secretion
22 Robust Recombinant Carbohydrate-Acting Enzymes for Biomass Utilization
23 Analysis of Boesenbergia rotunda whole genome and selected transcriptome for identfication of metabolic engineering targets


 The Malaysian Cohort (9th MP and 10th MP)

This programme aims to improve health and well-being of Malaysians through predictive medicine. The project components includes:

  • The recruitment of a population cohort of 100,000 individuals involving collection of high quality biospecimens and information on lifestyle.
  • Research programme for discovery of biomarkers for various diseases including cancers, diabetes, stroke, hypertension, ischaemic heart disease using genomics as well as gene-environment interaction studies
  • International collaboration with The Asia Cohort Consortium, Public Population Project in Genomics (P3G), The University of Oxford and The Broad Institute.


Science Fund Projects (10th MP)

NO.
PROJECT TITLE
1.
High Throughput Screen of Synthetic and Small Molecules as Anti-Infectives
2.
Post-genomic Discovery of Small Hypothetical Proteins from Bacillus lehensis G1 Alkaliphile
3.
Identification of Novel Enzymes for Total Utilization of Biomass via Transcriptomics of Termite Digestome
4.
Mining for robust extremozymes and unique secondary metabolites from an indigenous hyperthermopholic Geobacillus sp. through deep sequencing and computational approaches for industrial biotechnology applications.
5.
Elucidating the Gaharu Resin and Other Biosynthetic Pathways Using Large-Scale Transcriptome and Metabolite Profiling Via Comparison of Infected and Uninfected Trees
6.
Peptide Design and Synthesis Based on Enzyme Mimics for Industrial Needs
7.
Genome Based Robust Enzymes Discovery For Industrial Applications: Proteomics Identification of Secreted Enzymes from Bacillus lehensis G1
8.
Comparative Genomics of Clinical and Environment Burkholderia Pseudomallei to understand emergence of virulence.
9. Structural and Functional Genomics of Glyeoside and Peptide Hydrolases from the extramophiles Glaciozyma antarctica and Bacillus lehensis G1 for the Biobases Economy.


International Collaboration / Research Project

NO PROJECT
COLLABORATOR
1.
Dissecting the Host-Pathogen Enigma: The Case for Burkholderiapseudomallei
Stanford University (Tan Man Wah)
2.
Structural Genomics of the Extremophilic Microbes Leucosporidium antarticum and Bacillus lehensis G1
Monash University (Jamie Rossjohn)
3.
Structural Genomics of Burkholderia pseudomallei Essential Genes
University of Sheffield (David Rice)


Pre-Commercialisation Projects (10th MP)

NO

PROJECT

DURATION

1.
New Technologies for sustainable Bio-Economy : Construction of microbiol Cell Biocatalyst for Production of Biobased Fine Chemicals.
2 years
2.
Enhancing The therapeutic potential of rAF Newcastle Disease Virus Cancer Vaccine. 
2 years